2Introduction: Considering the importance of agrin, mTOR and AKT proteins in cognitive and physiological function, knowing the effects of different exercise programs is of particular importance. Aim: The purpose of this study was to investigate the responses of agrin, mTOR and AKT proteins in dual resistance-cognitive exercises of healthy people. Method: The research method is semi-experimental. 10 healthy men were randomly divided into two groups (resistance-cognitive group of 5 people and resistance group of 5 people). Resistance contraction included eccentric and concentric knee extension with maximum strength and speed. The contractions included 12 sets of 10 repetitions for the right leg, and in the cognitive group, cognitive task exercises included counting numbers in reverse, multiplying and dividing numbers, counting the months of the year, and counting coins simultaneously with facial resistance exercises. Took A biopsy was performed at the beginning and end of the study. To analyze the data, dependent t statistical method and covariance test were performed in SPSS21 software. Results: The results showed that the intra-group changes of mTOR and AKT proteins after one activity session were significant in the resistance-cognitive and resistance groups (p≤0.05). However, the inter-group changes of agrin, mTOR and AKT proteins showed no difference between the two groups. Conclusion: The present study showed that a session of resistance and resistance-cognitive activity leads to changes in the factors involved in the strength and hypertrophy of skeletal muscles. In addition, these changes are generally more resistance-cognitive in the resistance group.

Background: BDNF protein is the important neurotrophin that is involved in cognitive function. Diabetes can lead to impaired function and is a neurocognitive disorder's factor in hippocampus. Therefore, the purpose of this study was to evaluate the effect of 8 weeks of concurrent training on BDNF levels in the brain hippocampus and cognitive function of streptozotocin-induced diabetic rats. Methods: 40 of Sprague-Dawn rats were randomly divided into four groups: healthy inactive, non-healthy concurrent exercise, diabetic group without exercise, and diabetic concurrent exercise. Rats in the training groups performed concurrent training for 8 weeks. After 8 weeks, subjects' memory was assessed using a cognitive function test in a water maze. BDNF levels in the hippocampus were measured by Western blotting. One-way analysis of variance and LSD post hoc test were used to analyze the data. Findings: The present study showed that eight weeks of concurrent exercise resulted in a significant reduction in fasting blood sugar in the healthy exercise group compared to the diabetic group. A significant decrease in BDNF levels of the cerebral hippocampus was also observed in the diabetic exercise group compared to the diabetic group. In addition, the level of memory function in healthy exercise and diabetic exercise groups was significantly higher than healthy control and patient control. Conclusion: Concurrent exercise reduces BDNF hippocampus and increased cognitive function in the exercise group compared to the control group. As a result, it can be said that this type of exercise is very effective in improving the complications of type 2 diabetes.

Background and Aim: The necessity of maintaining effective cognitive function for the employees of ships is much more than for sedentary and low-risk jobs. The present study was conducted with the aim of comparing the cognitive performance before and after presenting different levels of noise in the employees of light vessels operating in the Persian Gulf. Methods: The current causal-comparative study was conducted in the first half of 1400 in the southern region of the country. The statistical population of the present study was all the employees of light vessels active in the Persian Gulf, and 15 people were placed in three groups with different noise ranges using the available sampling method. Posner's visual attention test was performed in the pre-test for all sample subjects. Then people of different buoyancy classes were then exposed to different noise ranges, and immediately after receiving the noise, the participants' Posner visual attention test was taken again. Data were analyzed using SPSS software. Results: The mean age of the subjects was 23.94 with a standard deviation of 3.25. The results showed that all components of the cognitive function of watchtower staff are different in both situations before and after exposure to sound. The results showed that the correct time response and the number of correct responses of individuals after the presentation of noise had a significant decrease and the reaction of the wrong time and the number of incorrect responses increased significantly. Conclusion: The results showed that exposure to acoustic vibrations at different frequencies affects selective attention and weakens the reaction time of correct responses.

obesity is one of the most serious problems of public health and the fifth leading cause of death. It is estimated that 44% of diabetic load, 23% of heart ischemic load and 7-41% of all cancers load are related to obesity. Approximately 80% of older adults (+65years) have at least one of the above mentioned chronic diseases, and 50% have at least two chronic disease (1). Along with other organs, brain is also affected with aging...